Exploring the Genomic Frontier using oligonucleotide microarrays containing millions of probes



Microarrays have long been used to examine gene transcription levels but with the use of tiling arrays much more information can now be obtained.  Tiling arrays can be used to scan the whole genome of organisms but require millions of probes to do so. The ability to change array designs rapidly allows researchers to scan the whole genome for disease loci at one resolution and then “zoom in” on the regions of interest to gather more information at ultra-high resolution.  Applications are growing almost daily – ChIP on chip, CGH, transcriptional mapping, nucleosome mapping, methylation, splice variant analysis, comparative genomic sequencing, histone analysis, etc.  In this talk we will show how researchers are using these new techniques to gain insight into autism, cancer, stem cell regulation, and drug resistance. 



Daniel B. Clutter, Ph.D.

Vice President

NimbleGen Systems, Inc.    (http://www.nimblegen.com)


Daniel B. Clutter, Ph.D. has been vice president-sales since January 2004. Dr. Clutter previously served as Director of Sales for PanVera/Invitrogen Corporation (5/2002 to 8/2003) where he led the High Throughput Drug Development Assay Sales Team. From 2001 to 2002, Dr. Clutter was Vice President of Business Development for Asterand, a provider of clinical tissue samples and tissue microarrays. Prior to Asterand, he served as Account Manager for Celera, a business group of Applera Corporation from 2000 to 2001, that provided early access to the privately sequenced genomes of human and mouse via subscription and proprietary software. Prior to Applera, Dr. Clutter served for 11 years (1988-2000) in various positions within Perkin Elmer Corporation, including Director of Midwest Sales and Service, National Sales Manager, Account Manager, National Support Manager, Western U.S. Support Manager, Northern California Branch Sales Manager and Application Specialist. After receiving a B.S. in biochemistry from Purdue University and a Ph.D. from the Pennsylvania State University, Dr. Clutter joined the faculty at Stockton State College where he taught chemistry and biochemistry from 1986 to 1988. 


时间: 2007年3月15日(星期)下午3:00-4:00





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