Exploring the Genomic
Frontier using oligonucleotide microarrays containing
millions of probes
Microarrays have long been used to examine gene
transcription levels but with the use of tiling
arrays much more information can now be obtained.
Tiling arrays can be used to scan the whole genome
of organisms but require millions of probes to do
so. The ability to change array designs rapidly
allows researchers to scan the whole genome for
disease loci at one resolution and then “zoom in” on
the regions of interest to gather more information
at ultra-high resolution. Applications are growing
almost daily – ChIP on chip, CGH, transcriptional
mapping, nucleosome mapping, methylation, splice
variant analysis, comparative genomic sequencing,
histone analysis, etc. In this talk we will show
how researchers are using these new techniques to
gain insight into autism, cancer, stem cell
regulation, and drug resistance.
Daniel B. Clutter, Ph.D.
NimbleGen Systems, Inc. (http://www.nimblegen.com)
Daniel B. Clutter, Ph.D. has been vice
president-sales since January 2004. Dr. Clutter
previously served as Director of Sales for PanVera/Invitrogen
Corporation (5/2002 to 8/2003) where he led the High
Throughput Drug Development Assay Sales Team. From
2001 to 2002, Dr. Clutter was Vice President of
Business Development for Asterand, a provider of
clinical tissue samples and tissue microarrays.
Prior to Asterand, he served as Account Manager for
Celera, a business group of Applera Corporation from
2000 to 2001, that provided early access to the
privately sequenced genomes of human and mouse via
subscription and proprietary software. Prior to
Applera, Dr. Clutter served for 11 years (1988-2000)
in various positions within Perkin Elmer
Corporation, including Director of Midwest Sales and
Service, National Sales Manager, Account Manager,
National Support Manager, Western U.S. Support
Manager, Northern California Branch Sales Manager
and Application Specialist. After receiving a B.S.
in biochemistry from Purdue University and a Ph.D.
from the Pennsylvania State University, Dr. Clutter
joined the faculty at Stockton State College where
he taught chemistry and biochemistry from 1986 to