DUB/JAMM module annotation

Members of JAMM family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors (1). This family is also known as the MPN domain and PAD-1-like domain JABP1 domain or JAMM domain, while the JAMM motif is critical for the activity (1-2). These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role (3).

1. http://pfam.sanger.ac.uk/family/PF01398

2. Verma, R., Aravind, L., Oania, R., McDonald, W.H., Yates, J.R., 3rd, Koonin, E.V. and Deshaies, R.J. (2002) Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science, 298, 611-615. PMID: 12183636

3. Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. and Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science, 298, 608-611. PMID: 12183637

>>>more in UUCD

Detail gene list for module DUB/JAMM

Protein	annotation
GRMZM2G086801	COP9 signalosome complex subunit 5b; Uncharacterized protein
GRMZM2G033626	26S proteasome non-ATPase regulatory subunit 14; Uncharacterized protein
GRMZM2G388576	-
GRMZM2G467059	26S proteasome non-ATPase regulatory subunit 14; Uncharacterized protein
GRMZM2G173119	Mov34/MPN/PAD-1 family protein; Uncharacterized protein