E2/UBC module annotation

UBC is the abbreviation of ubiquitin-conjugating. Most ubiquitin-conjugating enzymes (E2s) possess a core UBC domain, which contains the catalytic cysteine residue and interacts with E1s. E2 catalyzes the second step in the ubiquitination reaction, which targets a protein for degradation via the proteasome (1). Besides ubiquitination, E2s catalyzes ubiquitin-like modification. Once conjugated to ubiquitin or ubiquitin-like by E1 enzyme, the E2 enzyme binds one of several ubiquitin ligases or E3s via a structurally conserved binding region. Finally, the target protein substrate gets more and more ubiquitin molecules or ubiquitin-like molecules from E2 by E3.

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Detail gene list for module E2/UBC

Protein	annotation
GRMZM2G070047	Ubiquitin-conjugating enzyme E2 I
GRMZM2G150867	Ubiquitin-conjugating enzyme E2-21 kDa 1
GRMZM5G824629	-
GRMZM2G312693	-
GRMZM2G007381	Uncharacterized protein
GRMZM2G053764	Ubiquitin-conjugating enzyme E2-21 kDa 1
GRMZM2G116840	Uncharacterized protein
GRMZM2G022859	Uncharacterized protein
GRMZM2G120674	Uncharacterized protein
GRMZM2G102471	ubiquitin-conjugating enzyme 30
GRMZM2G038851	-
GRMZM2G341089	Ubiquitin-conjugating enzyme E2 I
GRMZM2G016176	-
GRMZM2G000601	Ubiquitin-conjugating enzyme E2-17 kDa
GRMZM2G113396	Ubiquitin-conjugating enzyme E2 E3
GRMZM2G022206	Ubiquitin-conjugating enzyme E2-17 kDa; Uncharacterized protein
GRMZM2G010460	Uncharacterized protein
GRMZM2G123519	Uncharacterized protein
GRMZM2G086583	-
GRMZM2G002830	Uncharacterized protein
GRMZM2G434519	-
GRMZM2G018447	Ubiquitin-conjugating enzyme E2 W; Uncharacterized protein
GRMZM2G007300	Ubiquitin-conjugating enzyme E2 7
GRMZM2G165511	Putative ubiquitin-conjugating enzyme family; Putative ubiquitin-conjugating enzyme family isoform 1; Putative ubiquitin-conjugating enzyme family isoform 2; Ubiquitin-conjugating enzyme E2-17 kDa; Uncharacterized protein
GRMZM5G862131	-
GRMZM5G814314	Ubiquitin-conjugating enzyme E2-17 kDa 9; Uncharacterized protein
GRMZM2G157605	Ubiquitin-conjugating enzyme family protein
GRMZM2G106143	Putative ubiquitin-conjugating enzyme family
GRMZM2G461533	Putative ubiquitin-conjugating enzyme family
GRMZM2G161545	Putative ubiquitin-conjugating enzyme family isoform 1; Putative ubiquitin-conjugating enzyme family isoform 2; Putative ubiquitin-conjugating enzyme family isoform 3; Ubiquitin-conjugating enzyme E2 16; Uncharacterized protein
AC233922.1_FG008	ubiquitin-conjugating enzyme 29
GRMZM2G007260	Uncharacterized protein
GRMZM2G090172	Uncharacterized protein
GRMZM2G148130	Uncharacterized protein
GRMZM2G146374	Uncharacterized protein
GRMZM2G115939	Putative RUB1 conjugating enzyme; Uncharacterized protein
GRMZM5G828302	Uncharacterized protein
GRMZM2G411771	-
GRMZM2G110983	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme E2-17 kDa; Uncharacterized protein
GRMZM2G102421	Putative ubiquitin-conjugating enzyme family isoform 1; Putative ubiquitin-conjugating enzyme family isoform 2; Putative ubiquitin-conjugating enzyme family isoform 3; Putative ubiquitin-conjugating enzyme family isoform 4; Uncharacterized protein
GRMZM5G895435	Putative ubiquitin-conjugating enzyme family; Uncharacterized protein
GRMZM2G116919	Uncharacterized protein
GRMZM2G156517	Putative ubiquitin-conjugating enzyme family; Uncharacterized protein
GRMZM2G012052	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme E2 7; Ubiquitin-conjugating enzyme protein E2; Uncharacterized protein
GRMZM2G085849	Ubiquitin-conjugating enzyme E2; Uncharacterized protein
GRMZM2G381709	Uncharacterized protein
GRMZM2G007122	Putative ubiquitin-conjugating enzyme family; Uncharacterized protein
GRMZM2G074479	Ubiquitin-conjugating enzyme E2-17 kDa; Uncharacterized protein
GRMZM2G433968	-
GRMZM2G173756	Uncharacterized protein
GRMZM2G072506	Ubiquitin-conjugating enzyme E2 E3; Uncharacterized protein
GRMZM2G007057	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme X; Uncharacterized protein
GRMZM2G078360	Uncharacterized protein
GRMZM2G122003	Uncharacterized protein
GRMZM2G027546	Uncharacterized protein
GRMZM2G015287	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme E2 N; Uncharacterized protein
GRMZM2G007276	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme E2; Uncharacterized protein
GRMZM2G132759	Putative ubiquitin-conjugating enzyme family
GRMZM2G086088	Putative ubiquitin-conjugating enzyme family isoform 1; Putative ubiquitin-conjugating enzyme family isoform 2; Putative ubiquitin-conjugating enzyme family isoform 3; Ubiquitin-conjugating enzyme E2-17 kDa 9
GRMZM2G115828	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme E2 N
GRMZM2G134176	Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2-22 kDa
GRMZM2G085600	Putative ubiquitin-conjugating enzyme family; Uncharacterized protein
GRMZM5G866947	Putative ubiquitin-conjugating enzyme family; Putative ubiquitin-conjugating enzyme family isoform 1; Putative ubiquitin-conjugating enzyme family isoform 2; Ubiquitin-conjugating enzyme E2-17 kDa; Uncharacterized protein
GRMZM2G177276	Ubiquitin conjugating enzyme 2
GRMZM2G464572	Uncharacterized protein
GRMZM2G153924	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme E2S
GRMZM2G163398	Putative ubiquitin-conjugating enzyme family isoform 1; Putative ubiquitin-conjugating enzyme family isoform 2
GRMZM2G121303	Putative ubiquitin-conjugating enzyme family; Uncharacterized protein
AC149818.2_FG006	Putative ubiquitin-conjugating enzyme family; Uncharacterized protein
GRMZM2G063931	Putative ubiquitin-conjugating enzyme family; Ubiquitin-conjugating enzyme E2 I