APC/C is a large multisubunit complex that consists of at least 10 subunits, APC1, APC2, APC3/CDC27, APC4, APC5, APC6/CDC16, APC8/CDC23, APC10/DOC1, APC11 and APC13, without containing proteins of CDC20 family here. In human, APC/C and CDC20 can form a 13 subunits containing ubiquitin ligase complex responsible for mediating defined cell cycle transitions. For instance, this unusual complex ubiquitin ligase can ubiquitinate and degrade cell-cycle-related proteins like cyclins and securing duiring mitosis and meiosis. Phosphorylation and inhibitors can regulate the APC/C and alter its substrate specificity at different phases of the cell cycle. Such strict control assures accurately timed degradation of critical cell-cycle regulators (1,2).
>>>more in UUCD |
