UBD/Alpha-Helix/UBA module annotation

The ubiquitin-associated (UBA) domain is an approximately 40 amino acid motif that was first recognized in proteins associated with ubiquitination but is also found in proteins involved in DNA nucleotide excision-repair and other proteins (1). UBA domains have been shown to bind mono-, di-, tri-, and tetra-ubiquitin in vitro but appear to bind to polyubiquitin with a higher affinity and it is thought that polyubiquitinated proteins represent the true in vivo binding substrates. As well, some UBA domains appear to homo and heterodimerize and to bind other substrates. Functionally, the UBA domain has been proposed to limit ubiquitin chain elongation and to target ubiquitinated proteins to the 26S proteasome for degradation. Evidence that ubiquitin binds to UBA domains leads to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin (2).

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Detail gene list for module UBD/Alpha-Helix/UBA

Protein	annotation
GRMZM2G137366	Uncharacterized protein
GRMZM2G392956	-
GRMZM2G057158	Uncharacterized protein
GRMZM2G000923	Nascent polypeptide-associated complex alpha subunit-like protein
GRMZM2G136769	Uncharacterized protein
GRMZM2G093855	RHOMBOID-like protein 15
GRMZM2G107187	SEC-C motif-containing protein / OTU-like cysteine protease family protein
GRMZM2G070881	ubiquitin-associated (UBA)/TS-N domain-containing protein
GRMZM2G139846	-
GRMZM2G021299	Uncharacterized protein
GRMZM2G105772	Uncharacterized protein
GRMZM2G158872	Uncharacterized protein
GRMZM2G070264	chromatin remodeling 8
GRMZM2G157316	Uncharacterized protein
GRMZM2G411536	-
GRMZM2G071739	UBA/TS-N domain; Uncharacterized protein
GRMZM2G085836	CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), PUB domain (InterPro:IPR018997), PUG domain (InterPro:IPR006567), UBA-like (InterPro:IPR009060); BEST Arabidopsis thalia /.../tein match is: ubiquitin-associated (UBA)/TS-N domain-containing protein (TAIR:AT1G04850.1); Has 7001 Blast hits to 5165 proteins in 492 species: Archae - 9; Bacteria - 505; Metazoa - 2653; Fungi - 905; Plants - 287; Viruses - 19; Other Eukaryotes - 2623 (source: NCBI BLink).
GRMZM2G025806	Uncharacterized protein
GRMZM2G143462	Uncharacterized protein
GRMZM2G092447	Uncharacterized protein
GRMZM2G175272	DCN1-like protein 2; Uncharacterized protein
GRMZM2G077278	Putative SNF1-related protein kinase family protein
GRMZM2G061620	Uncharacterized protein
GRMZM2G107696	Ubiquitin carboxyl-terminal hydrolase
GRMZM2G107556	Putative DUF1767 domain containing protein
GRMZM2G134176	Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2-22 kDa
GRMZM2G071249	Uncharacterized protein
GRMZM2G035417	DNA repair protein RAD23; Uncharacterized protein
GRMZM2G344499	Uncharacterized protein
GRMZM2G170843	Ubiquilin-1; Uncharacterized protein
GRMZM2G127101	Ubiquilin-1; Uncharacterized protein
GRMZM2G092497	Putative DNA cytosine methyltransferase Zmet3 isoform 1; Putative DNA cytosine methyltransferase Zmet3 isoform 2; Putative DNA cytosine methyltransferase Zmet3 isoform 3; Uncharacterized protein
GRMZM2G331368	Uncharacterized protein