TissueCFM000723 module
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Protein:Yellow color--query protein Green color--interaction proteins.
Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontology |
|---|---|---|
| proteasome core complex, alpha-subunit complex | 0.005536059 | GO:0019773 |
| large ribosomal subunit | 0.005536059 | GO:0015934 |
| proteasome core complex | 0.005536059 | GO:0005839 |
| threonine-type endopeptidase activity | 0.022194566 | GO:0004298 |
| endopeptidase activity | 0.022194566 | GO:0004175 |
| protein_peptidyl-prolyl_isomerization | 0.027887086 | GO:0000413 |
| proteolysis involved in cellular protein catabolic process | 0.027887086 | GO:0051603 |
| peptidyl-prolyl cis-trans isomerase activity | 0.028854912 | GO:0003755 |
| protein folding | 0.042885239 | GO:0006457 |
| ubiquitin-dependent protein catabolic process | 0.042885239 | GO:0006511 |
| Proteasome | 0.016806439 | KEGG |
| Cationic antimicrobial peptide (CAMP) resistance | 0.021257673 | KEGG |
Module member annotation
| Gene ID | Annotation | Ortholog in Arabidopsis (Blast e-value) |
|---|---|---|
| Solyc01g111450.2 | proteasome alpha subunit D2 | AT3G51260 (7.00E-119) |
| Solyc02g065720.2 | RING/U-box superfamily protein | AT5G38895 (3.00E-60) |
| Solyc02g081310.2 | Ribosomal protein L18e/L15 superfamily protein | AT5G64670 (2.00E-72) |
| Solyc06g008700.2 | Transducin/WD40 repeat-like superfamily protein | AT1G03110 (9.00E-140) |
| Solyc11g006070.1 | Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein | AT2G16600 (7.00E-58) |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TissueCFM000704 | thiamine biosynthetic process thiamine-phosphate diphosphorylase activity Transcription_related, Transcription factor: GRAS thiamin diphosphate biosynthesis IV (eukaryotes) thiamin salvage IV (yeast) 4-methyl-5(β-hydroxyethyl)thiazole salvage (yeast) hydroxymethylpyrimidine salvage 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis thiamin salvage II thiamin formation from pyrithiamine and oxythiamine (yeast) putrescine biosynthesis II putrescine biosynthesis IV Thiamine metabolism Arginine and proline metabolism | details |
| TissueCFM000713 | thiamine biosynthetic process thiamine-phosphate diphosphorylase activity thiamin diphosphate biosynthesis IV (eukaryotes) 4-methyl-5(β-hydroxyethyl)thiazole salvage (yeast) 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis hydroxymethylpyrimidine salvage thiamin salvage IV (yeast) thiamin salvage II thiamin formation from pyrithiamine and oxythiamine (yeast) Thiamine metabolism | details |
| TissueCFM000722 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity pteridine-containing compound metabolic process proteasome core complex, alpha-subunit complex large ribosomal subunit proteasome core complex folic acid-containing compound biosynthetic process endopeptidase activity threonine-type endopeptidase activity proteolysis involved in cellular protein catabolic process ubiquitin-dependent protein catabolic process tetrahydrofolate biosynthesis 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I tetrahydrofolate biosynthesis II Proteasome Folate biosynthesis | details |
| TissueCFM000910 | nuclear mRNA splicing, via spliceosome mRNA processing spliceosomal complex snRNA_binding RNA processing Transcription_related, Transcription regulator: SWI/SNF-BAF60b Hippo signaling pathway -fly | details |
| TissueCFM000930 | threonine-type endopeptidase activity proteolysis involved in cellular protein catabolic process proteasome core complex endopeptidase activity proteasome core complex, alpha-subunit complex ubiquitin-dependent protein catabolic process vacuolar transport Proteasome | details |
| TissueCFM001075 | thymidine kinase activity transferase activity Ubiquitin_Proteasome_system, E3 adaptor: DWD folate polyglutamylation glycine biosynthesis pyrimidine deoxyribonucleosides salvage 5-aminoimidazole ribonucleotide biosynthesis I photorespiration folate transformations II Antifolate resistance Drug metabolism - other enzymes | details |
| TissueCFM001076 | lysine biosynthetic process via diaminopimelate dihydrodipicolinate reductase activity Ubiquitin_Proteasome_system, E3 adaptor: DWD lysine biosynthesis VI Monobactam biosynthesis Hippo signaling pathway -fly | details |
| TissueCFM001128 | mitochondrial matrix peptidyl-prolyl cis-trans isomerase activity protein_peptidyl-prolyl_isomerization protein folding Cationic antimicrobial peptide (CAMP) resistance | details |
| TissueCFM001136 | DNA replication | details |
| TissueCFM001182 | proteolysis involved in cellular protein catabolic process proteasome core complex threonine-type endopeptidase activity proteasome core complex, alpha-subunit complex endopeptidase activity ubiquitin-dependent protein catabolic process calmodulin binding Proteasome Alzheimer's disease | details |
| TissueCFM001183 | proteolysis involved in cellular protein catabolic process proteasome core complex threonine-type endopeptidase activity proteasome core complex, alpha-subunit complex endopeptidase activity ubiquitin-dependent protein catabolic process protein N-linked glycosylation beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity calmodulin binding formation of glycosidic bonds, GlycosylTransferases: GTnc Proteasome N-Glycan biosynthesis Alzheimer's disease | details |
| TissueCFM001229 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity pteridine-containing compound metabolic process proteasome core complex, alpha-subunit complex proteasome core complex endopeptidase activity folic acid-containing compound biosynthetic process threonine-type endopeptidase activity mitochondrion double-stranded DNA binding proteolysis involved in cellular protein catabolic process Transcription_related, Transcription factor: mTERF tetrahydrofolate biosynthesis 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I tetrahydrofolate biosynthesis II triacylglycerol biosynthesis Proteasome Folate biosynthesis Choline metabolism in cancer | details |
| TissueCFM001233 | ribosome structural constituent of ribosome large ribosomal subunit translation protein_peptidyl-prolyl_isomerization peptidyl-prolyl cis-trans isomerase activity protein folding Cationic antimicrobial peptide (CAMP) resistance | details |
Expression profiles
 Show details about module gene expression profiling |