TreatCFM001360 module
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Protein:Yellow color--query protein Green color--interaction proteins.
Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontology |
|---|---|---|
| proton-transporting two-sector ATPase complex, catalytic domain | 0.012580506 | GO:0033178 |
| cis-Golgi network | 0.012580506 | GO:0005801 |
| ATP metabolic process | 0.019952124 | GO:0046034 |
| proton transport | 0.019952124 | GO:0015992 |
| ER to Golgi vesicle-mediated transport | 0.019952124 | GO:0006888 |
| mRNA processing | 0.019952124 | GO:0006397 |
| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | 0.024292923 | GO:0016820 |
| ribonuclease III activity | 0.024292923 | GO:0004525 |
| ATP hydrolysis coupled proton transport | 0.02479717 | GO:0015991 |
| RNA processing | 0.034845174 | GO:0006396 |
| Oxidative phosphorylation | 0.020592545 | KEGG |
| RNA degradation | 0.020592545 | KEGG |
| Proteoglycans in cancer | 0.020592545 | KEGG |
Module member annotation
| Gene ID | Annotation | Ortholog in Arabidopsis (Blast e-value) |
|---|---|---|
| Solyc01g100820.2 | Clathrin adaptor complexes medium subunit family protein | AT1G56590 (0) |
| Solyc01g111690.2 | SNARE-like superfamily protein | AT2G20930 (5.00E-70) |
| Solyc01g111760.2 | ATPase, V1 complex, subunit B protein | AT4G38510 (0) |
| Solyc03g117030.1 | Polynucleotidyl transferase, ribonuclease H-like superfamily protein | AT2G32070 (7.00E-130) |
| Solyc03g119010.2 | modifier of snc1,4 | AT3G18165 (1.00E-88) |
| Solyc04g011500.2 | actin-11 | AT3G12110 (0) |
| Solyc07g049160.2 | RNAse II-like 1 | AT4G15417 (2.00E-55) |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM000198 | isomerase activity ribonuclease III activity RNA processing glucose and glucose-1-phosphate degradation sucrose biosynthesis II UDP-glucose biosynthesis sucrose degradation III (sucrose invertase) starch biosynthesis Glycolysis / Gluconeogenesis Type II diabetes mellitus Proteoglycans in cancer | details |
| TreatCFM000201 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor metalloendopeptidase activity Transcription_related, Transcription factor: CPP L-glutamine biosynthesis II (tRNA-dependent) triacylglycerol biosynthesis Protein processing in endoplasmic reticulum Aminoacyl-tRNA biosynthesis Fat digestion and absorption Hippo signaling pathway -fly | details |
| TreatCFM000447 | G-protein coupled receptor signaling pathway FMN binding signal transducer activity guanyl nucleotide binding acyl-CoA dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors G-protein_beta/gamma-subunit_complex_binding GTPase activity two-component signal transduction system (phosphorelay) oxidation-reduction process flavin adenine dinucleotide binding Transcription_related, Transcription regulator: Orphans Aminobenzoate degradation | details |
| TreatCFM000523 | details | |
| TreatCFM000525 | SAGA-type_complex aspartic-type endopeptidase activity transcription_corepressor_activity microtubule Protein_kinases_phosphatases, PPC:3.1.1: Casein Kinase I Family | details |
| TreatCFM000541 | core TFIIH complex nucleotide-excision repair nuclease activity ATP-dependent DNA helicase activity unfolded protein binding Base excision repair Alzheimer's disease | details |
| TreatCFM000546 | Parkinson's disease | details |
| TreatCFM000548 | Transcription_related, Transcription factor: trihelix Vibrio cholerae infection hydrolysis and/or rearrangement of glycosidic bonds， Glycoside Hydrolases： GH89 | details |
| TreatCFM000668 | N,N-dimethylaniline monooxygenase activity NADP binding flavin adenine dinucleotide binding | details |
| TreatCFM000717 | acyl-CoA metabolic process acyl-CoA_hydrolase_activity charged-tRNA amino acid modification tRNA A64-2'-O-ribosylphosphate transferase activity oligosaccharyltransferase complex protein N-linked glycosylation acyl-CoA hydrolysis ω-hydroxylation of caprate and laurate Protein processing in endoplasmic reticulum Bile secretion | details |
| TreatCFM000718 | charged-tRNA amino acid modification tRNA A64-2'-O-ribosylphosphate transferase activity SUMO_transferase_activity FMN binding | details |
| TreatCFM000732 | Vibrio cholerae infection Chemical carcinogenesis | details |
| TreatCFM000757 | microtubule GTPase activity microtubule-based process cell redox homeostasis Nicotinate and nicotinamide metabolism Vibrio cholerae infection | details |
| TreatCFM000809 | microtubule microtubule-based process GTPase activity methyltransferase activity mRNA surveillance pathway Nicotinate and nicotinamide metabolism | details |
| TreatCFM000848 | Protein_kinases_phosphatases, PPC:4.5.4: GSK3/Shaggy Like Protein Kinase Family RNA degradation | details |
| TreatCFM000924 | histone_H3_acetylation spindle pole microtubule organizing center regulation_of_DNA_methylation Ino80_complex exocyst microtubule cytoskeleton organization exocytosis histone acetyltransferase activity Transcription_related, Transcription factor: faR1 Ubiquitin_Proteasome_system, E3: RING Transcription_related, Transcription regulator: PHD Transcription_related, Transcription regulator: SNF2 | details |
| TreatCFM000992 | glycerone kinase activity glycerol metabolic process Arp2/3_protein_complex cytoskeleton actin_filament_organization Arp2/3_complex-mediated_actin_nucleation FMN binding formation of glycosidic bonds, GlycosylTransferases: GTnc cytokinin-O-glucosides biosynthesis Zeatin biosynthesis RIG-I-like receptor signaling pathway Aminobenzoate degradation | details |
| TreatCFM001006 | proteolysis involved in cellular protein catabolic process proteasome core complex threonine-type endopeptidase activity ubiquitin-dependent protein catabolic process Proteasome | details |
| TreatCFM001135 | Platinum drug resistance | details |
| TreatCFM001166 | GTP binding | details |
| TreatCFM001176 | glycerol metabolic process tRNA aminoacylation glycerone kinase activity tRNA binding cytoplasm aminoacyl-tRNA ligase activity Transcription_related, Transcription regulator: SNF2 tRNA charging Aminoacyl-tRNA biosynthesis RIG-I-like receptor signaling pathway | details |
| TreatCFM001199 | vesicle_fusion_with_Golgi_apparatus Golgi vesicle transport exocytosis Golgi membrane protein transporter activity exocyst intracellular protein transport | details |
| TreatCFM001264 | histone_H3_acetylation regulation_of_DNA_methylation histone acetyltransferase activity Transcription_related, Transcription regulator: SNF2 Transcription_related, Transcription factor: faR1 Transcription_related, Transcription regulator: PHD Transcription_related, Transcription factor: B3 UTP and CTP dephosphorylation II pyrimidine deoxyribonucleotides de novo biosynthesis I | details |
| TreatCFM001280 | endoplasmic reticulum membrane adhesion to carbohydrates, Carbohydrate-Binding Modules: CBM48 Transcription_related, Transcription factor: bZIP | details |
| TreatCFM001304 | SUMO_transferase_activity cell redox homeostasis protein ubiquitination Ubiquitin_Proteasome_system, E3: RING Vibrio cholerae infection | details |
| TreatCFM001373 | mRNA guanylyltransferase activity ubiquitin-specific_protease_activity 7-methylguanosine mRNA capping protein tyrosine/serine/threonine phosphatase activity protein_deubiquitination mRNA processing protein dephosphorylation Ubiquitin_Proteasome_system, DUB: OTU Transcription_related, Transcription factor: C2H2 mRNA surveillance pathway | details |
| TreatCFM001396 | GTP binding endoplasmic reticulum membrane small GTPase mediated signal transduction | details |
| TreatCFM001402 | histone_H2A_acetylation negative_regulation_of_transcription,_DNA-templated histone_H4_acetylation NuA4_histone_acetyltransferase_complex chromatin remodeling DNA repair Transcription_related, Transcription factor: MYB-RELATED | details |
| TreatCFM001412 | microtubule protein_deubiquitination microtubule-based process ubiquitin-specific_protease_activity GTPase activity Ubiquitin_Proteasome_system, DUB: OTU Ubiquitin_Proteasome_system, E3 adaptor: DWD Proteasome Nicotinate and nicotinamide metabolism | details |
| TreatCFM001429 | protein phosphorylation protein kinase activity ATP binding Protein_kinases_phosphatases, PPC:4.1.1: MAP3K Platinum drug resistance | details |
| TreatCFM001455 | sulfide oxidation III (sulfur dioxygenase) Sulfur metabolism | details |
| TreatCFM001458 | mediator complex regulation of transcription from RNA polymerase II promoter RNA_polymerase_II_transcription_cofactor_activity N-acetyltransferase_activity Transcription_related, Transcription regulator: MED7 Protein_kinases_phosphatases, PPC:1.2.2: Receptor Like Cytoplasmic Kinase VII Transcription_related, Transcription regulator: GNAT formation of glycosidic bonds, GlycosylTransferases: GTnc | details |
| TreatCFM001571 | protein tyrosine/serine/threonine phosphatase activity protein dephosphorylation mediator complex regulation of transcription from RNA polymerase II promoter RNA_polymerase_II_transcription_cofactor_activity N-acetyltransferase_activity Transcription_related, Transcription regulator: MED7 Transcription_related, Transcription regulator: GNAT phosphatidylglycerol biosynthesis I (plastidic) cardiolipin biosynthesis II phosphatidylglycerol biosynthesis II (non-plastidic) Glycerophospholipid metabolism EGFR tyrosine kinase inhibitor resistance Endocrine resistance | details |
| TreatCFM001578 | hydrolase activity methylglyoxal degradation I pyridine nucleotide cycling (plants) L-ascorbate biosynthesis I (L-galactose pathway) Ascorbate and aldarate metabolism Pyruvate metabolism RNA degradation | details |
| TreatCFM001588 | formation of glycosidic bonds, GlycosylTransferases: GTnc | details |
| TreatCFM001619 | ER to Golgi vesicle-mediated transport cis-Golgi network | details |
| TreatCFM001648 | Golgi_transport_complex RNA degradation | details |
Expression profiles
 Show details about module gene expression profiling |