TreatCFM000476 module
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Protein:Yellow color--query protein Green color--interaction proteins.
Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontology |
|---|---|---|
| microtubule-based process | 0.004168098 | GO:0007017 |
| microtubule | 0.004598486 | GO:0005874 |
| GTPase activity | 0.023250362 | GO:0003924 |
| protein binding | 0.044487772 | GO:0005515 |
| Ubiquitin_Proteasome_system, E3 adaptor: DWD | 0.000383779 | gene family |
| Nicotinate and nicotinamide metabolism | 0.007177691 | KEGG |
Module member annotation
| Gene ID | Annotation | Ortholog in Arabidopsis (Blast e-value) |
|---|---|---|
| Solyc01g100050.2 | TOPLESS-related 3 | AT5G27030 (0) |
| Solyc02g083940.2 | Transducin/WD40 repeat-like superfamily protein | AT5G66240 (3.00E-155) |
| Solyc04g007100.2 | protein phosphatase 2A subunit A3 | AT3G25800 (0) |
| Solyc04g081490.2 | tubulin beta-1 chain | AT1G75780 (0) |
| Solyc11g007320.1 | Galactose oxidase/kelch repeat superfamily protein | AT2G36360 (2.00E-179) |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM000231 | microtubule protein glycosylation microtubule-based process GTPase activity galactosyltransferase activity carbohydrate binding Transcription_related, Transcription factor: trihelix Transcription_related, Transcription factor: bZIP formation of glycosidic bonds, GlycosylTransferases: GTnc UTP and CTP de novo biosynthesis Pyrimidine metabolism Nicotinate and nicotinamide metabolism Glycosaminoglycan biosynthesis - heparan sulfate / heparin hydrolysis and/or rearrangement of glycosidic bonds， Glycoside Hydrolases： GH89 | details |
| TreatCFM000283 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity protein binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Ubiquitin_Proteasome_system, E3 adaptor: DWD Transcription_related, Transcription regulator: SWI/SNF-BAF60b Ubiquitin_Proteasome_system, E3 adaptor: Cullin Transcription_related, Transcription factor: SBP GDP-mannose biosynthesis tetrapyrrole biosynthesis I (from glutamate) L-ascorbate biosynthesis I (L-galactose pathway) Protein processing in endoplasmic reticulum Biofilm formation - Pseudomonas aeruginosa hydrolysis and/or rearrangement of glycosidic bonds， Glycoside Hydrolases： GH89 | details |
| TreatCFM000294 | microtubule chloride transport transferase activity voltage-gated chloride channel activity microtubule-based process GTPase activity folate transformations II photorespiration folate polyglutamylation glycine biosynthesis Nicotinate and nicotinamide metabolism Antifolate resistance | details |
| TreatCFM000334 | magnesium_ion_transport small GTPase mediated signal transduction signal transducer activity magnesium_ion_transmembrane_transporter_activity Transcription_related, Transcription factor: STAT | details |
| TreatCFM000389 | electron-transferring-flavoprotein dehydrogenase activity magnesium_ion_transport Cytochrome_P450, Cytochrome P450: CYP89A valine degradation I poly-hydroxy fatty acids biosynthesis beta-Alanine metabolism MicroRNAs in cancer | details |
| TreatCFM000412 | microtubule microtubule-based process Transcription_related, Transcription factor: bZIP L-ascorbate biosynthesis I (L-galactose pathway) GDP-mannose biosynthesis Nicotinate and nicotinamide metabolism Biofilm formation - Pseudomonas aeruginosa Hippo signaling pathway -fly | details |
| TreatCFM000454 | fucosyltransferase_activity nucleic acid binding microtubule-based process protein glycosylation microtubule GTPase activity formation of glycosidic bonds, GlycosylTransferases: GTnc Nicotinate and nicotinamide metabolism Various types of N-glycan biosynthesis Herpes simplex infection | details |
| TreatCFM000455 | microtubule-based process microtubule GTPase activity regulation of actin filament polymerization Arp2/3_complex-mediated_actin_nucleation Arp2/3_protein_complex actin cytoskeleton nucleosome assembly nucleosome Transcription_related, Transcription factor: C2C2-GATA Transcription_related, Transcription factor: MYB-RELATED asparagine degradation I Cyanoamino acid metabolism Nicotinate and nicotinamide metabolism | details |
| TreatCFM000525 | SAGA-type_complex aspartic-type endopeptidase activity transcription_corepressor_activity microtubule Protein_kinases_phosphatases, PPC:3.1.1: Casein Kinase I Family | details |
| TreatCFM000558 | microtubule microtubule-based process Transcription_related, Transcription factor: bZIP Ubiquitin_Proteasome_system, DUB: USP Nicotinate and nicotinamide metabolism | details |
| TreatCFM000572 | riboflavin kinase activity voltage-gated chloride channel activity chloride transport riboflavin biosynthetic process small GTPase mediated signal transduction flavin biosynthesis I (bacteria and plants) Riboflavin metabolism | details |
| TreatCFM000680 | polysaccharide catabolic process microtubule microtubule-based process beta-amylase activity GTPase activity Transcription_related, Transcription factor: BES1 Purine metabolism Nicotinate and nicotinamide metabolism hydrolysis and/or rearrangement of glycosidic bonds， Glycoside Hydrolases： GH89 | details |
| TreatCFM000757 | microtubule GTPase activity microtubule-based process cell redox homeostasis Nicotinate and nicotinamide metabolism Vibrio cholerae infection | details |
| TreatCFM000809 | microtubule microtubule-based process GTPase activity methyltransferase activity mRNA surveillance pathway Nicotinate and nicotinamide metabolism | details |
| TreatCFM000839 | microtubule microtubule-based process acid phosphatase activity GTPase activity phosphate acquisition GDP-mannose biosynthesis L-ascorbate biosynthesis I (L-galactose pathway) Nicotinate and nicotinamide metabolism Biofilm formation - Pseudomonas aeruginosa Tuberculosis | details |
| TreatCFM001015 | microtubule-based process microtubule protein ubiquitination Protein_kinases_phosphatases, PPC:4.1.1: MAP3K Transcription_related, Transcription factor: trihelix Transcription_related, Transcription factor: SBP GDP-mannose biosynthesis UTP and CTP de novo biosynthesis L-ascorbate biosynthesis I (L-galactose pathway) Pyrimidine metabolism Nicotinate and nicotinamide metabolism Biofilm formation - Pseudomonas aeruginosa hydrolysis and/or rearrangement of glycosidic bonds， Glycoside Hydrolases： GH89 | details |
| TreatCFM001016 | microtubule-based process microtubule GTPase activity Protein_kinases_phosphatases, PPC:4.1.1: MAP3K Transcription_related, Transcription factor: SBP Nicotinate and nicotinamide metabolism | details |
| TreatCFM001073 | mitochondrion_organization RNA modification pseudouridine synthesis ATP-dependent_5'-3'_DNA_helicase_activity methionine biosynthesis II Selenocompound metabolism Toluene degradation | details |
| TreatCFM001171 | microtubule-based process microtubule GTPase activity Ubiquitin_Proteasome_system, DUB: OTU Ubiquitin_Proteasome_system, E3 adaptor: DWD Nicotinate and nicotinamide metabolism | details |
| TreatCFM001341 | microtubule microtubule-based process GTPase activity hydroxyacylglutathione hydrolase activity phosphoribosylanthranilate isomerase activity methylglyoxal_catabolic_process_to_D-lactate tryptophan metabolic process biosynthetic process coenzyme A biosynthesis I methylglyoxal degradation I tryptophan biosynthesis Pyruvate metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Pantothenate and CoA biosynthesis Nicotinate and nicotinamide metabolism | details |
| TreatCFM001370 | regulation of signal transduction microtubule-based process microtubule Transcription_related, Transcription factor: SBP Transcription_related, Transcription factor: bZIP GDP-mannose biosynthesis L-ascorbate biosynthesis I (L-galactose pathway) Nicotinate and nicotinamide metabolism Biofilm formation - Pseudomonas aeruginosa | details |
| TreatCFM001399 | microtubule-based process microtubule GTPase activity coenzyme binding pyrimidine nucleobases salvage I superpathway of pyrimidine ribonucleosides salvage superpathway of pyrimidine nucleobases salvage pyrimidine ribonucleosides salvage I pyrimidine salvage pathway choline biosynthesis III plant sterol biosynthesis phosphatidate metabolism, as a signaling molecule phospholipases Steroid biosynthesis Nicotinate and nicotinamide metabolism Pyrimidine metabolism Choline metabolism in cancer Drug metabolism - other enzymes | details |
| TreatCFM001410 | microtubule microtubule-based process GTPase activity hydrolase activity aspartic-type endopeptidase activity pyrimidine salvage pathway guanosine nucleotides degradation II guanosine nucleotides degradation I adenosine nucleotides degradation I UTP and CTP dephosphorylation I Nicotinate and nicotinamide metabolism Purine metabolism | details |
| TreatCFM001412 | microtubule protein_deubiquitination microtubule-based process ubiquitin-specific_protease_activity GTPase activity Ubiquitin_Proteasome_system, DUB: OTU Ubiquitin_Proteasome_system, E3 adaptor: DWD Proteasome Nicotinate and nicotinamide metabolism | details |
| TreatCFM001457 | ubiquitin ligase complex ubiquitin-ubiquitin ligase activity membrane coat microtubule intracellular protein transport microtubule-based process vesicle-mediated transport protein ubiquitination ubiquitin-dependent protein catabolic process GTPase activity Ubiquitin_Proteasome_system, E3: U-box Nicotinate and nicotinamide metabolism | details |
| TreatCFM001494 | microtubule-based process microtubule chromatin binding GTPase activity Nicotinate and nicotinamide metabolism | details |
| TreatCFM001523 | ATP-dependent_5'-3'_DNA_helicase_activity DNA helicase activity ATP binding Herpes simplex infection Viral carcinogenesis | details |
| TreatCFM001554 | microtubule microtubule-based process heat shock protein binding GTPase activity unfolded protein binding Transcription_related, Transcription factor: bZIP Ubiquitin_Proteasome_system, E3 adaptor: DWD Nicotinate and nicotinamide metabolism | details |
Expression profiles
 Show details about module gene expression profiling |