TissueCFM000797 module
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Protein:Yellow color--query protein Green color--interaction proteins.
Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontology |
|---|---|---|
| threonine-type endopeptidase activity | 3.15469E-05 | GO:0004298 |
| proteolysis involved in cellular protein catabolic process | 3.15469E-05 | GO:0051603 |
| proteasome core complex | 3.15469E-05 | GO:0005839 |
| endopeptidase activity | 0.005221818 | GO:0004175 |
| proteasome core complex, alpha-subunit complex | 0.005221818 | GO:0019773 |
| ubiquitin-dependent protein catabolic process | 0.039197358 | GO:0006511 |
| Proteasome | 5.80E-05 | KEGG |
| Base excision repair | 0.009304834 | KEGG |
Module member annotation
| Gene ID | Annotation | Ortholog in Arabidopsis (Blast e-value) |
|---|---|---|
| Solyc02g070510.2 | 20S proteasome alpha subunit E2 | AT3G14290 (2.00E-133) |
| Solyc04g045590.2 | oxidoreductase, 2OG-Fe(II) oxygenase family protein | AT1G11780 (6.00E-120) |
| Solyc11g066610.1 | AT1G08220 (1.00E-78) | |
| Solyc11g069150.1 | 20S proteasome beta subunit G1 | AT1G56450 (1.00E-116) |
| Solyc12g088730.1 | Ribosomal protein L4/L1 family | AT2G20060 (4.00E-136) |
| Solyc12g089140.1 | Erythronate-4-phosphate dehydrogenase family protein | AT1G75180 (1.00E-92) |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TissueCFM000290 | iron_ion_transmembrane_transport iron ion transmembrane transporter activity integral to membrane GTP binding | details |
| TissueCFM000494 | lipid transport lipid transporter activity mRNA processing formation of glycosidic bonds, GlycosylTransferases: GTnc Transcription_related, Transcription regulator: C3H xylogalacturonan biosynthesis Hippo signaling pathway -fly | details |
| TissueCFM000561 | Arp2/3_protein_complex intracellular transport actin_filament_organization Arp2/3_complex-mediated_actin_nucleation formation of glycosidic bonds, GlycosylTransferases: GTnc dolichyl-diphosphooligosaccharide biosynthesis N-Glycan biosynthesis | details |
| TissueCFM000609 | protein insertion into membrane Ubiquitin_Proteasome_system, E3 adaptor: DWD triacylglycerol degradation Retrograde endocannabinoid signaling Herpes simplex infection | details |
| TissueCFM000622 | L-phenylalanine biosynthetic process protein N-linked glycosylation prephenate dehydratase activity beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity formation of glycosidic bonds, GlycosylTransferases: GTnc phenylalanine biosynthesis II phenylalanine biosynthesis (cytosolic, plants) | details |
| TissueCFM000689 | proteasome core complex proteolysis involved in cellular protein catabolic process threonine-type endopeptidase activity proteasome core complex, alpha-subunit complex endopeptidase activity ubiquitin-dependent protein catabolic process Ubiquitin_Proteasome_system, DUB: JAMM Proteasome | details |
| TissueCFM000796 | Base excision repair | details |
| TissueCFM000904 | prefoldin complex lipoate biosynthetic process ribosome lipoate synthase activity aminoacyl-tRNA_editing_activity translation 4 iron, 4 sulfur cluster binding structural constituent of ribosome lipoate biosynthesis and incorporation II lipoate biosynthesis and incorporation I tRNA charging Lipoic acid metabolism Aminoacyl-tRNA biosynthesis | details |
| TissueCFM001181 | proteolysis involved in cellular protein catabolic process proteasome core complex threonine-type endopeptidase activity proteasome core complex, alpha-subunit complex endopeptidase activity ubiquitin-dependent protein catabolic process Ubiquitin_Proteasome_system, DUB: JAMM Proteasome | details |
| TissueCFM001183 | proteolysis involved in cellular protein catabolic process proteasome core complex threonine-type endopeptidase activity proteasome core complex, alpha-subunit complex endopeptidase activity ubiquitin-dependent protein catabolic process protein N-linked glycosylation beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity calmodulin binding formation of glycosidic bonds, GlycosylTransferases: GTnc Proteasome N-Glycan biosynthesis Alzheimer's disease | details |
| TissueCFM001184 | Arp2/3_protein_complex actin cytoskeleton Arp2/3_complex-mediated_actin_nucleation regulation of actin filament polymerization protein glycosylation galactosyltransferase activity Protein_kinases_phosphatases, PPC:1.2.2: Receptor Like Cytoplasmic Kinase VII formation of glycosidic bonds, GlycosylTransferases: GTnc Glycosaminoglycan biosynthesis - heparan sulfate / heparin Platinum drug resistance | details |
| TissueCFM001359 | transcription elongation from RNA polymerase II promoter Golgi vesicle transport histone modification vesicle docking Cdc73/Paf1 complex protein glycosylation exocytosis galactosyltransferase activity endoplasmic reticulum Protein_kinases_phosphatases, PPC:1.2.2: Receptor Like Cytoplasmic Kinase VII formation of glycosidic bonds, GlycosylTransferases: GTnc Glycosaminoglycan biosynthesis - heparan sulfate / heparin | details |
| TissueCFM001383 | protein_prenylation protein N-linked glycosylation via asparagine protein prenyltransferase activity endoplasmic reticulum membrane protein ubiquitination cell redox homeostasis Protein processing in endoplasmic reticulum Vibrio cholerae infection | details |
| TissueCFM001431 | CAAX-box_protein_processing phosphatidylinositol phosphorylation metalloendopeptidase activity peptidase activity D-myo-inositol (1,4,5)-trisphosphate degradation Phosphatidylinositol signaling system Terpenoid backbone biosynthesis | details |
Expression profiles
 Show details about module gene expression profiling |